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doi: 10.1016/j.abb.2017.11.007 80

Metabolic effects: Hypoglycemia (IGF-1 binds insulin receptor at high concentrations), insulin resistance with chronic elevation, altered glucose homeostasis

Across multiple clinical studies in Hashimoto thyroiditis, metformin has also been associated with lower TSH and thyroid autoantibody levels [148]

In mammals, the core clock genes include CLOCK , BMAL1 , PER1 / 2 / 3 , and CRY1 / 2

(Lausanne) 12 , 761834 (2021)

This study helps to elucidate the mechanisms mediating the expression of aromatase in hGL cells and provides a potential mechanism explaining the high E2 levels in patients with OHSS