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Most protocols deliver 1 to 3 mg per day subcutaneously, either daily or 5 days on with 2 days off

Funding Financial support by the Joint International Research Unit (JIRU) for Chemical and Biomolecular Research on the Microbiome and its impact on Metabolic Health and Nutrition (MicroMeNu) and by the Sentinelle Nord Program of Universit Laval (to N.F, L.C., and V.D.), which in turn is funded by the Canada First/Apoge program of the Tri-Agency of the Canadian Federal Government

Similarly, Ji et al

It is of particular importance to focus our studies on the molecular and biochemical mechanisms of colistin-induced nephrotoxicity in order to facilitate the achievement of the best-possible colistin therapy outcome: loading dose to reduce or even clear the infection in the shortest possible time, limiting resistance development

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Methods: The 8-week-old db/m and db/db mice were given low, medium, and high doses of TSWN as well as valsartan by gavage for 12 weeks, respectively