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Recent data from our own laboratory, where we see increased GSTP1 expression in a novel drug-resistant A2780 subline immediately following de novo platinum selection, further support the hypothesis that increased GSTP1 expression may not be maintained in long-term culture of immortalised tumour cells

It is important to state that two separate folate cycles coexist in the cell, one in the cytosol and one in the mitochondria with different isoforms of 5,10-methylene-THF dehydrogenases (MTFHR) (Figure 2)