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Iwasa, M

Ramachandran A, Horvath CM

The mechanism of action of APR-246, which is based on GSH depletion and induction of ferroptosis, makes it the first ferroptosis-inducing agent currently used therapeutically in humans

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In early-stage PD patients, somatic mtDNA point mutations are markedly elevated in SN dopaminergic neurons, with respiratory chain defects resulting from mtDNA deletions being particularly prominent (117, 118)