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Glutamate/GABA-Glutamine Cycle Astrocytes participate in the fast removal of neurotransmitters from the synaptic cleft, which is important for efficient signal termination (53)

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The identified prognostic signature provides a robust tool for predicting patient outcomes and may inform the development of targeted therapies aimed at modulating GSH metabolism and enhancing antitumor immunity in LUAD, thereby facilitating improved treatment decision-making and identification of high-risk populations requiring close follow-up

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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing