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Prof Douglas Higgs, also from Oxford University, pointed out that not all the patients had become free of transfusions and there was still little known about the long-term effects of manipulating the genome of stem cells in this way

In RBCs damaged proteins and enzymes are not discarded and replaced as the biochemical machinery for these tasks was lost upon differentiation of the progenitor cells to mature erythrocytes

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10.1074/jbc.r200006200 40 Pacheu-GrauD.RucktschelR.DeckersM

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