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Simultaneously, inflammation can result in oxidative stress (67, 68)

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21 This enzyme is responsible for reducing glutathione disulfide (GSSG) to its sulfhydryl form, known as glutathione (GSH), a potent endogenous antioxidant agent

Certainly, these therapies are effective, but they most often lead to severe long-term complications such as infections, Secondary malignancy, ovarian failure, disturbances in gastrointestinal tract functionality, miscellaneous hematologic conditions that include leucopenia or anemia, organ damage, and long-term use of corticosteroids may lead to weight gain, delivery of osteoporosis, and diabetes mellitus ( Literature reviews regarding the association of probiotics with lupus indicate that they may have beneficial contributions to immune regulation and inflammation, two pivotal components in lupus pathogenesis

In addition, the ratios of C5DC to C5-OH and C8 to C2 were significantly positively associated with fracture, but the ratios of C4 to C8, C5 to C0, C5 to C2, C5 to C3, C5-OH to C8, C5-OH to C0, C3DC to C10, and C5DC to C8 were negatively associated with fracture