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Melatonin also exerts antiestrogenic activity, which is particularly significant in hormone-dependent tumors, regulating the expression and transactivation of the estrogen receptor, and modulating the enzymes involved in the local synthesis of estrogens

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

They are generally well tolerated with rare minor adverse effects

Splitting the dose or choosing sustained-release or liposomal formats enhances absorption

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Of particular interest, dysregulated iron metabolism plays a distinct role in BPD-associated pyroptosis