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Beyond Wilsons disease, other states of impaired copper handling warrant caution including advanced liver disease

marinum and Cortes et al

Power analysis and advanced statistics can potentially help to reduce the number of replicates ( While pseudo-replication due to the re-use of animals can be compensated for using Bayesian statistics ( Pagurus bernhardus ( The number of replicates should then be carefully decided based on such previous experiments with the chosen model organisms

The Watanabe 2012 trial demonstrated statistically significant melanin reduction using topical 2% glutathione formulations

CHRIS: It is indeed plausible

It can downregulate pro-ferroptosis proteins ACSL4 and 5-lipoxygenase (5-LOX), and reduce microgliosis and astrogliosis to promote recovery after SCI (Pang et al., 2022)