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Systematic translation requires coordinated efforts across realistic timescales

This functional loss may stem from age-related phagocytic exhaustion and the direct toxicity of iron-rich A and tau aggregates toward microglia (155) Furthermore, prior cell culture studies confirm that amyloid exposure accelerates microglial senescence (156)

doi: 10.1038/cmi.2014.89 215 PedreB.BarayeuU.EzeriaD.DickT

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Furthermore, DNA technology can now be integrated with next-generation therapeutic platforms, because of the advancement in genomic engineering in recent years

CY 2022 performance data were the most recently available data in time for us to construct our simulation model for this final rule and for the same reasons discussed in the CY 2024 PFS final rule (88 FR 79504), we are considering it to construct the baseline and policies model in this final rule