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The above studies consistently point out that DNA methylation may play a crucial role in the regulation of ferroptosis mechanisms in AD

Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice

doi: 10.1007/s00432-012-1150-1 120 BleckmannAConradiLCMenckKSchmickNASchubertARietkotterEet al

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Similar findings were observed in the brainstem and cerebellum indicating that these effects are not region-specific but rather reflect a more brain-wide neuroinflammatory and antioxidant modulation

It is a potent free-radical scavenger and can directly neutralize ROS, thereby protecting neurons from oxidative stress-induced apoptosis