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We found that the glycolytic flux into the TCA cycle was reduced in Gclc fl/fl Mb1-Cre + FoB compared to Gclc fl/fl FoB, as indicated by increased M3-lactate and reduced M2-citrate (Supplementary Fig

as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011