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Additionally, check to see if your patient is taking medications that can cause B12 deficiency

photocatalysis (UV-A) Dyes (e.g., methylene blue), PAHs, heavy metals (Pb2+, Cd2+), pharmaceuticals Q max: 200500 mg g1 (for dyes/metals) Aggregates in hard water

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When oxygen is sparse, HIF-1 promotes mitophagy and inhibits mitochondrial biogenesis by upregulating BNIP3 expression and inhibiting c-Myc-dependent mitochondrial generation (Sowter et al., 2001