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The strongest clinical evidence: a 2019 randomized, double-blind 12-week trial in the British Journal of Dermatology (n=44) found 0.5% bakuchiol and 0.5% retinol produced comparable reductions in wrinkle surface area and hyperpigmentation, with retinol users reporting significantly more facial scaling and stinging

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Here we provide molecular and functional evidence that explains how either pre-existing or newly synthesized misfolded polypeptides are selectively recognized and form an aggresome that is eventually eliminated by aggrephagy

References Nebert DW, Wain HM: Update on human genome completion and annotations: Gene nomenclature