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In chemical carcinogenesis models of breast cancer, it has also been demonstrated that synthetic vitamin D analogs increase tumor latency and decrease tumor incidence and recurrence ( Unlike humans, sheep, cattle, horses, pigs, rats, and other mammals, dogs and cats cannot produce vitamin D in their skin by sunlight ( The body responds to calcitriol in a pleiotropic way via the VDR receptor, a transcription factor that is a part of the nuclear hormone receptor family

The choice between subcutaneous (SubQ) injection and topical application isn't just a matter of convenience

doi: 10.3389/fmars.2022.967748

doi:10.1097/ede.0000000000000804

Whilst one meta-analysis of five RCTs found no significant improvements in any of the BD scores, 81 another meta-analysis of six studies found a significant effect of NAC on Clinical Global Impression-Severity Scale (CGI-S) score, but not any other scores

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