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doi: 10.1016/j.tibs.2025.01.009

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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

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Instead, its mechanism is fundamentally different: it activates the bodys own healing signals rather than replacing or suppressing natural hormones

Fibroblasts are the cells responsible for producing collagen and other extracellular matrix components that form the structural basis of fascia