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Here, we show how sub-physiological levels of B12 in the host antagonizes Mtb virulence, and describe a yet unknown mechanism of host-pathogen cross-talk with implications for B12 anemic populations

Despite substantial treatment crossover and informative censoring, the COBALT RCT showed a non-statistically significant efficacy signal in favor of OCA treatment, and both the COBALT EC and HEROES trial emulation studies showed statistically significant superiority of OCA vs non-treatment

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2020;216:117-127.e2