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Grade A evidence includes multi-center cohort studies and meta-analyses with large sample sizes providing the strongest evidence base (81)

Winkle M, El-Daly SM, Fabbri M, Calin GA (2021) Noncoding RNA therapeutics challenges and potential solutions

1 It is noteworthy that the absolute number of breast cancer cases is increasing in many developing countries due to population growth and the adoption of western lifestyles

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These findings shed light on the role of innate enteric immunity in regulating the intestinal microbiota fulfilled by Paneth cell -defensin in the early-life period, with a relatively limited immune system when adaptive immunity, with the exception of IgA, remains immature