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Additionally, oral doses of B12 can be effective, providing a convenient method of administration with comparable bioavailability to other forms

However, it remains a preclinical compound: unapproved by the FDA, prohibited under WADAs Schedule 0 category, and without a single completed, published human trial

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Plateau Breaking Strategies Researchers who observe diminishing returns after extended use may employ several strategies: Brief Dose Increase : Temporarily increasing dose by 25-30% for 1-2 weeks may overcome adaptation, followed by return to standard dosing