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Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities

doi: 10.1002/j.1939-4640.2003.tb02641.x 163 FernandezJLMurielLGoyanesVSegrellesEGosalvezJEncisoMet al

: 3

In addition to cytochrome P450 enzymes, efflux transporters expressed at the bloodbrain barrier (BBB) critically shape central nervous system (CNS) exposure to psychotropic drugs (O'Brien et al., 2012a

Therefore, the SELEX procedure was performed using a ssDNA oligonucleotides library

First, D 2 O 2 binding occludes the only entrance to the active site and may potentially block substrate from entering since the Tyr166-His30-PEO-Tyr34 network is composed of several SSHBs (Fig