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Since phenylacetyl disulfide lacks stereoselectivity, the resulting oligonucleotides are racemic mixtures (108)

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It is important to note that while the influence of these non-ADE factors can be mitigated, it cannot be entirely eliminated

Furthermore, the optimization of ferroptosis inducer delivery through advanced nanomedicine approaches, such as engineered nanocarriers, tumor-targeted exosomes, or BBB-penetrating delivery systems, could significantly enhance therapeutic efficacy while minimizing systemic toxicity and off-target effects

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