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We found that treatment of sagittal brain slices with 1 mM CPZ alone induced demyelination of the corpus callosum, reducing MBP expression to ~51% and MOG expression to ~53% of untreated slices, 24 h post-treatment

Moreover, the role of variation in drug metabolizing enzymes between different individuals and its possible impact on the hepatic injury induced by these drugs is discussed here

Consistently, SOD1 G93A transgenic mice exhibited ferroptotic features and neurotoxic glial activation resembling those observed in ALS patient spinal cords and in vitro models

Neutrophils as critical orchestrators of chronic inflammation

Several studies have explored the potential link between chronic inflammation and carcinogenesis in the prostate, suggesting that long-standing inflammation may create an environment conducive to cancer development

Ermakov VS, Granados JC, Nigam SK