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Ganeshan DM, Correa AM, Bhosale P, Vaporciyan AA, Rice DC, Mehran RJ, Walsh GL, Iyer R, Roth JA, Swisher SG , Hofstetter WL

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The R620W polymorphism in PTPN22 is associated with several autoimmune diseases and likely disrupts T-cell regulation, enhancing autoimmunity and contributing to the development of GD ( CD40 ) is involved in B-cell activation and antibody production under normal physiological conditions

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Edwards et al., Figure 1 (C) Reduction (detoxification) of fatty acid hydroperoxides to corresponding hydroxy derivatives by the peroxidase activity of GST as described by Bartling et al