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29 GSH, the major cellular antioxidant in mammalian systems, is synthesized from glutamate, cysteine, and glycine through the sequential actions of glutamine-cysteine ligase and glutathione synthetase

The GPX family, which consists of eight isozymes (GPX1-8), is the most prominent group of proteins in the crucial redox system of mammalian cells (10)

Cytochrome p450 CYP2C9 is likely to be a major CYP isoform catalyzing fluoxetine N-demethylation in human liver microsomes at a substrate concentration close to the therapeutic level, while polymorphic CYP2C19 may play a more important role in this metabolic pathway at high substrate concentration

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