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Treatment doses typically range from 50 to 150 g daily of cyanocobalamin, preferably taken between meals, or 1,000 g daily for more rapid repletion, continued until deficiency is corrected

As the insulin receptor is expressed in all cell types and insulin signaling mediates diverse cellular functions, the detailed insulin function of each tissue has been extensively studied using tissue-specific Insr knockout mice 3,5 , in which Insr expression is almost completely disrupted in a specific cell type

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A vitamin B12 deficiency can cause numerous symptoms, and the condition can also be overlooked or confused with other deficiencies or conditions

(For this reason, taking a vitamin B12 supplement is essential for vegans, and may be particularly helpful for those with low stomach acid , until the condition is corrected

In the latter case, the drug is used only when the expected benefit to the female outweighs the potential risk to the young