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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

Indeed, CYPs are promiscuous in their capacity to bind and metabolize multiple substrates ( see Table 62)

Crystalloid fluids supplemented with fortified B vitamins, including thiamine, riboflavin, niacinamide, d-panthenol, pyridoxine, and cyanocobalamin, should be used

Viscosupplementation refers to the injection of a hyaluronan preparation into the joint

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