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192 The tumor extracellular matrix (ECM), primarily composed of dense collagen fibers, hyaluronan, fibronectin, periostin, and other macromolecules, forms a physical and biochemical barrier that significantly limits the penetration and distribution of therapeutic agents, including nanoparticles, cytokines, and PRR agonists

& von Moltke, L

M9a + sh EPAS1 cells attenuate inflammation by enhancing mitophagy under hypoxia To investigate the mechanism of Tibetan adaptation to hypoxia, RNA sequencing was performed on three cell lines (M7/8+shCTR, M9a+shCTR, M9a+sh EPAS1 )

However, this technique is often debated because it relies on population averages that may not apply to the specific individual

doi: 10.1161/JAHA.124.034203 60 FanCLiangWWeiMGouXHanSBaiJ

isoDCA, isodeoxycholic acid