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They are typical signs of weakened cell-cell junctions and impaired ECs that can enhance the paracellular permeability and facilitate the trans-endothelial migration of tumor cells [95]

DOI: 10.1038/nrm2101 80

Research indicates that silibinin effectively inhibits tumor growth across a broad spectrum of cancers such as breast, ovarian, lung, colon, pancreatic, liver, renal cell, endometrial, and bladder cancers [879]

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