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30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown

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Neuropsychopharmacology 37 , 13051320 (2012)

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New York: 1989

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doi: 10.1038/mp.2017.171 184 ZilleMKaruppagounderSSChenYGoughPJBertinJFingerJet al

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