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Description

Brainfog and sensory overload decreased the most (3.8 and 3.6 pts, respectively), muscle pain and weakness responded the least (2.1 and 1.9 pts, respectively)

doi: 10.1128/aac.01087-13 394 SuH.ZhuM.TsuiC

Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy