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(2000) identified a C-terminal RSRR retention motif in GABA B R1 that retains the receptor on the endoplasmic reticulum, thus preventing surface expression

Interestingly, mechanistic studies revealed that Plasmodium -derived hemozoin that accumulated in TAMs abrogated IGF-1R signaling partly by silencing its downstream targets PI3K and MAPK, causing decreased expression of tumor angiogenesis facilitator matrix metalloprotease 9 (MMP-9) in TAMs, and in turn leading to decreased tumor angiogenesis and TAM infiltration (34)

Sandau, U

10.1002/path.2094 126 ThorntonJ

There are numerous well-known NAD+-dependent enzymes

PMID 2899993