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The AMYRs are heterodimers formed by combining a cell surface expressed calcitonin G protein coupled receptor (CTR) with any one of three transmembrane proteins, known as receptor activity modifying proteins (RAMPs)

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To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration

Neuroregulation : It interacts with the nitric oxide (NO) and dopamine systems, potentially aiding in nerve repair and mood stabilization

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