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By Matthew Solan Executive Editor, Harvard Men's Health Watch image: Celso Pupo Rodrigues | Dreamstime.com

3.1 T1D-associated genes: impact on immune function Approximately 40-50% of the genetic risk of developing T1D is attributed to the class I and II MHC/HLA region, with class II being the most significant, as it is essential to the adaptive immune system ( Figure 1 ) (50)