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10.1186/s12935-019-0902-2 374 WangC.ZhangY.CaoJ.YangZ

the CNS pathology is one of a neurodegenerative disorder, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), cerebrovascular accidents (CVA: ischemic stroke, intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH)), vascular-related dementia, brain trauma (traumatic brain injury), spinal cord injury, alcoholism, Prion diseases: Creutzfeldt- Jakob disease (CJD), bovine spongiform encephalopathy (BSE)

The demethylation process occurs through a -KG-dependent mechanism, in which oxygen is activated to oxidize the methyl group on the histone substrate

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Milk Thistle supports liver health, contributes to the detoxifying potential of theliver & helps to protect the liver which in turn maintain theliver function and addtionaly promote the digestion andthe bodys purification*

The cornerstone of treatment involves chelation therapy using intravenous disodium calcium edetate (EDTA-CaNa2) and iron supplementation