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increased lipid metabolism caused by FFAs is linked to insulin resistance [148,149] because it inhibits the insulin receptor [150,151]

Mitochondrial respiration was measured using the Seahorse XFe96 analyzer which provides four major indices of mitochondrial respiration [25]

Shoji et al., 2000

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When iron homeostasis is perturbed, excess Fe 2+ catalyzes Fenton chemistry to produce highly reactive hydroxyl radicals (OH), triggering lipid peroxidation and cellular injury