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Notably, some of these peptides (e.g., biphalin [154]) exhibit not only potent analgesic effects but also support wound healing processesan additional benefit in the treatment of painful chronic wounds

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It would move if well-conducted, adequately powered, independent randomized trials of at-home non-needle RF, isolated from LED and not funded by the device maker, failed to show firmness or wrinkle benefit, in which case the home-RF recommendation would weaken to "delivery and surface only." It would also move if higher-quality human trials of infused PDRN, GHK-Cu, or EGF for facial anti-aging either confirmed a clear outcome, which would let EvenSkyn upgrade the serum grade, or repeatedly failed, which would push the serum claim to "delivery aid, no independent anti-aging effect." If either body of evidence arrives, this article will be updated with a dated entry in the log below stating exactly what changed

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