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Because Phase I leaves behind dangerous, reactive intermediates, Phase II must quickly neutralize them

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[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Yakar S

2.3 -syn-driven pathogenic cascade 2.3.1 -syn aggregation and mitochondrial dysfunction -syn is a protein that is highly expressed in the central nervous system, comprising approximately 1% of the total neuronal protein (Haque et al., 2022

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29 Both acute and chronic stress signaling via hormones and neurotransmitters can increase thrombosis risk by increasing platelet numbers, reactivity, and aggregation, disrupting normal vascular function, up-regulating the clotting cascade, and altering fibrinolysis mechanisms