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The autotaxin enzyme that synthesizes LPA is selectively localized to excitatory synapses and is absent in inhibitory synapses (Thalman et al., 2020)

We then highlight two mechanisms by which IGF-1 exerts its anabolic action on the skeleton

Other reported NRF2 agonists with potential AD-modifying effects include flavonoids (eriodictyol), polyphenols (tannic acid), terpenoids (ginkgolide B), and lignans (forsythiaside A) (324327) ( Figure 7 )

Tissue & Cell, 61, 820

A direct link to Ca 2+ sequestration has been proposed for oxaliplatin, whose metabolites includes a Ca 2+ chelating oxalate moiety

While the results suggest potential benefit (Garg et al., 2019)