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It revealed a strong attenuation of otherwise sustained paralysis (in control rats) in the rats treated with NaBPC157

10.1152/physrev.00013.2010 Physiol

73.5% reached HbA1c 6.5% vs 15.9% placebo

The lactams 33 and 34 comprising 14-membered ring systems were most active in the series but nonetheless 100-fold less potent than the best disulfide and carba analogues (Barlow et al., 2020)