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The effects of chronic stress on BDNF levels are well-documented, with stress-induced reductions in BDNF being associated with the onset of depressive symptoms

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98,99 Traditional tribal remedies include Achyranthes bidentata , Ardisia solanacea , Flourensia cernua , and Phoradendron californicum , which have been used for centuries to treat stomach infections, diarrhea, and dysentery through antimicrobial and anti-inflammatory actions

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