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The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation

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These advances not only improve drug bioavailability, but also reduce the frequency of administration, thereby improving patient compliance

Mullaney JA, Stephens JE, Costello ME, Fong C, Geeling BE, Gavin PG, et al

MEFs lacking Bmal1 showed lower CI respiration, reduced SAM levels and decreased NDUFS2 methylation (Fig