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Development and characterization of high efficacy cell-penetrating peptide via modulation of the histidine and arginine ratio for gene therapy

Decreased levels of GSH in WT SOD1 expressing mice were associated with fewer motor neurons and a shorter average lifespan (Killoy et al., 2018)

Genes (basel) 11(11):1295

Urate, also known as uric acid, is a major endogenous antioxidant that is neuroprotective against both astrocyte-induced toxicity in SOD1 G93A mice and H 2 O 2 induced oxidative stress in cells expressing mutant SOD1 G93A (Bakshi et al., G85R cellular and Drosophila models (Zhang et al., 2019b)

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In the context of hematopoietic cell transplantation, the administration of exogenous IL-7 can facilitate T cell reconstitution, thereby promoting the homeostatic proliferation of T cells and conferring antiapoptotic effects on peripheral T cells