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These data suggest mitragynine likely behaves as a 5-HT 1A R agonist in vivo, though with substantially lower potency than speciogynine and paynantheine, paralleling mitragynines much lower affinity at 5-HT 1A Rs

Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J, Mackinnon AL, Parlati F, Rodriguez ML, Shwonek PJ, Sjogren EB, Stanton TF, Wang T, Yang J, Zhao F, Bennett MK

Although the experience of dermabrasion is quite intense, some patients are ideal candidates for this type of procedure

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Sandalio LM, Romero-Puertas MC