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However, with the continuous use of targeted drugs, some patients exhibit resistance

Erasmus JJ, Munden RF, Truong MT , Ho JJ, Hofstetter WL, Macapinlac HA, Correa AM, Wu TT, Bruzzi JF, Marom EM, Sabloff BS, Ajani JA, Komaki R, Liao Z, Lee JH, Fukami N, Bresalier R, Swisher SG

doi: 10.1002/cphy.c130024

Subsequent research in PD mouse models demonstrated a toxic synergy between mutant -syn (-syn-A53T) and iron deposition, inducing cellular senescence in the SN prior to DA neuron loss and the onset of motor deficits (Shen Q

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Apparently, SARS-CoV-2 may enter the brain by the olfactory pathways and spread to the basal ganglia, brainstem, and piriform and infralimbic cortex [25]