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In related experiments, overexpression of PTP1B in HEK 293T cells inhibited ARE-mediated luciferase expression after treatment with APAP for 16 h (Figure 4e), reinforcing the involvement of PTP1B in Nrf2-mediated antioxidant response to APAP

Finally, one of these structures reveals that C20, 29 away from each Fe(II) atom in the opposite protomer is persulfidated (PDB 28MT) or sulfonated (28MU), the significance of which is unknown

A total of 991 chemicals were annotated by DeepCDM upon non-targeted analysis with an average annotation efficiency 30 times better than that of SIRIUS 4 and 80 times better than that of CD 3.3