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However, cardiac PDE5 expression was reported to be upregulated in hypertrophic, dilated, and ischemic cardiomyopathy and in congestive heart failure [47,145,146]

The shared ototoxic mechanisms of noise exposure and various drugs or chemical compounds may elucidate the potentiation of hearing loss resulting from combined exposure to these agents

Mitochondrial energy metabolism disorders not only affect cell function, but also cause systemic metabolic abnormalities, and inducing age-related diseases

doi: 10.3389/fendo.2023.1148556 48

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