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Silver nanoparticles (AgNPs) act through multiple mechanisms: releasing Ag ions that disrupt bacterial membranes, generating ROS, and binding thiol groups in enzymes to block essential metabolic processes [76]

In another study, caffeines anti-depressant and anti-inflammatory effects were comparable to those of caffeinated coffee but were not observed with decaffeinated coffee [32]

Figure 2 3.1 B vitamins (B12, B6 or others if found) in late onset AD There is a documented relationship between Hcy B vitamins and an increased risk of cognitive impairment and AD

Primary handling editors: Ibrahim Javed and Benjamin Bessieres

Annu Rev Cell Dev Biol (2017) 33:491510

Medications, if used, should supplement other interventions