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Disclosures: Jun Tsuchiya: Nothing to Disclose, Masato Miyoshi: Nothing to Disclose, Sei Kakinuma: Nothing to Disclose, Taro Shimizu: Nothing to Disclose, Keiya Watakabe: Nothing to Disclose, Tomohiro Mochida: Nothing to Disclose, Kento Inada: Nothing to Disclose, Shun Kaneko: Nothing to Disclose, Fukiko Kawai-Kitahata: Nothing to Disclose, Sayuri Nitta: Nothing to Disclose, Miyako Murakawa: Nothing to Disclose, Mina Nakagawa: Nothing to Disclose, Yasuhiro Asahina: Nothing to Disclose, Ryuichi Okamoto: Nothing to Disclose 1807 METTL3-MEDIATED M6A MODIFICATION REGULATES THE POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) COMPONENTS BMI1 AND RNF2 IN HEPATOCELLULAR CARCINOMA CELLS Weina Chen Jinqiang Zhang 1 Wenbo Ma 1 Nianli Liu 1 Tong Wu 1 , 1 Tulane University Background: Methyltransferase- like 3 (METTL3) is a primary RNA methyltransferase that catalyzes N6-methyladenosine (m6A) modification which is implicated in several human cancers including hepatocellular carcinoma (HCC), although its mechanism of action remains to be further defined