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In CRC, valosin-containing protein (VCP) upregulates CPT1 expression by accelerating HDAC1 degradation to enhance FAO and tumor progression (120), while CPT1A-mediated FAO suppresses anoikis to facilitate metastasis (121)

Individual effect of GST genotypes was shown for GSTM1 active genotype decreasing the risk of ASD (OR = 0.554, 95%CI: 0.3130.983, p = 0.044), and for GSTA1 CC genotype, increasing susceptibility to ASD (OR = 4.132, 95%CI: 1.21914.012, p = 0.023)

Also, studies have shown that sperm quality and function is enhanced with a regular intake of carnitine and acetyl carnitine as it acts to safeguard the sperm and cell membrane against ROS-induced DNA fragmentation and apoptosis