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Induction of Monocyte Chemoattractant Protein-1 (MCP-1) and its Receptor CCR2 in Primary Sensory Neurons Contributes to Paclitaxel-Induced Peripheral Neuropathy

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By attaching a larger molecule, like a polyethylene glycol (PEG) chain (a process called PEGylation), scientists can make the peptide too large to be easily filtered by the kidneys and can also sterically hinder the approach of degrading enzymes

As a result, orthopaedic surgeons are increasingly asked by their patients to counsel them on the risks, benefits, and emerging data surrounding peptide-based interventions

Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schlager C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, et al